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On Friday, May 31, 2024, the Institute for Biological Research “Siniša Stanković” – an Institute of national importance for the Republic of Serbia, University of Belgrade celebrated 77 years since the establishment. On this occasion, the Institute organized a traditional celebration. The first part of the celebration was the scientific part comprising of a series of lectures, which was followed by a festive part and awards ceremony. Dr Danijela Drakulić had a great honour to present STREAMLINE project as an esteemed guest during scientific segment of this program.

Dan Instituta 2024 (bg.ac.rs)

U četvrtak 16. maja u Svečanoj Sali Rektorata Univerziteta u Beogradu održan je prvi STREAMLINE „Industry open day“. Učesnici su imali prilike da se kroz seriju predavanja iz oblasti nauke i inovacija upoznaju sa STREAMLINE projektom, radom Sektora za transfer tehnologija Instituta za molekularnu genetiku i genetičko inženjerstvo Univerziteta u Beogradu, primerom nastanka Spin-out kompanije, povezanošću istraživanja i industrije, koracima koji su potrebni od fundamentalnog istraživanja do komercijalne održivosti, strategijom prekliničkih istraživanja potencijalnih terapeutika, preprekama i izazovima za primenu ćelijske terapije u kliničkoj praksi i istraživanjima u dečijoj i adolescentnoj psihijatriji kao preduslov za efikasne rane intervencije. Ovo je bila dobra prilika za umrežavanje, povezivanje, uzajamno druženje i razmenu iskustava između akademskih eksperata, savetnika za komercijalizaciju istraživanja i predstavnika farmaceutskih kuća.

Na ovom događaju svečano je obeleženo formiranje STREAMLINE HUB-a, organizacione jedinice koja za cilj ima da okupi entuzijaziste iz oblasti istraživanja neurorazvojnih poremećaja, a sve u cilju pronalaženja rešenja za ova sve češća oboljenja savremenog sveta.

Hvala svima na učešću. Vidimo se na sledećem STREAMLINE „Industry open day“-u.

We are pleased to announce that our first paper within STREAMLINE Project is now published online in the journal Children (Basel).

22q11.2 deletion syndrome (22q11.2DS), the most frequent microdeletion syndrome in humans, is related to a high risk of developing neurodevelopmental disorders. About 95% of patients with 22q11.2DS have speech and language impairments. Global articulation, story generation, and verbal memory tests were applied to compare articulatory characteristics of speech sounds, spontaneous language abilities, and immediate verbal memory between four groups of Serbian-speaking children: patients with 22q11.2DS, children with clinical presentation of 22q11.2DS that do not have the microdeletion, children with non-syndromic congenital heart defects, and their peers with typical speech–sound development. The obtained results showed that children with this microdeletion have impaired articulation skills and expressive language abilities. However, we did not observe weaker receptive language skills and immediate verbal memory compared to healthy controls. Children with 22q11.2DS should be considered a risk category for the development of speech–sound pathology and expressive language abilities. Since speech intelligibility is an instrument of cognition and adequate peer socialization, and language impairment in school-aged children with 22q11DS might be an indicator of increased risk for later psychotic symptoms, patients with 22q11.2 microdeletion should be included in a program of early stimulation of speech–language development immediately after diagnosis is established.

Ivana Simeunović and Jovana Kostić presented their research within the STREAMLINE project at the Belgrade Neuroscience Next Hub 2024 conference held in Belgrade from April 24 to 25, 2024.

The World Association for Alzheimer’s Disease and AAIC Neuroscience Next organized Hybrid Conference on Neuroscience – Belgrade Neuroscience Next 2024, held on April 24 and 25, 2024 at the Faculty of Medicine of the University of Belgrade. This conference aim was to provide a platform for researchers, especially young researchers, to engage in discussion, share research results and foster collaboration in the field of neuroscience. This was a great opportunity for our colleagues to increase the visibility of the STREAMLINE Project outputs among academic public and to socialize with other young researchers who are enthusiast for neuro sciences.

Prvi STREAMLINE “Industry open day” biće organizovan 16. maja 2024. u Svečanoj sali Rektorata, Univerzitet u Beogradu, Studentski trg broj 1.

TokomSTREAMLINE projekta ovladali smo procesom reprogramiranja mononuklearih ćelija periferne krvi u indukovane pluripotentne matićne ćelije (iPSCs), procesom neuralne diferencijacije, generisanjem organoida, -omics analizama, što nam omogućava ne samo modelovanje neurorazvojnih poremećaja već i ostalih oboljenja koji imaju genetičku osnovu, kao i testiranje potencijalnih terapeutika u bolest- i bolesnik- specifičnom model sistemu.

Ovom prilikom biće predstavljen Institut za molekularnu genetiku i genetičko inženjerstvo Univerzitet u Beogradu kao regionalni centar za proučavanje i modelovanje neurorazvojnih promećaja koji je ekvivaletnog istraživačkog kapaciteta i kodeksa prakse kao i slični centri u Evropi. Takođe, imaćete prilike da čujete  o primerima dobre prakse saradnje industrije i istraživačkih institucija, kao i o istraživanjima koja su dala značajne rezultate u medicini. Na taj način ovim skupom želimo da doprinesemo daljem povezivanju i partnerstvu istraživačkih i medicinskih institucija i farmaceutskog sektora.