The training dedicated to improving the research management capabilities and administrative skills of IMGGE staff was held online on January 13, 2025. This year, the training program was elevated to a higher level by integrating the topics covered in the previous six trainings into one comprehensive program. IMGGE staff who had submitted project proposals that did not receive funding in the recent period or, who are currently preparing or planning to prepare EU or other international proposals, were offered personalized advice. Dr. Marija Schwirtlich and Dr. Danijela Drakulic presented their project proposals, which had been evaluated over the past two years. Following their presentations, a discussion occurred with Prof. David Linden, Prof. Adrian Harwood, Dr. Spyros Petrakis, and Marco Berndes (Funding and Policy Advisor). They provided Marija and Danijela with feedback and main suggestions to improve the quality of their proposed studies.
It is our great pleasure to announce our third Spring school: “Emerging technologies and new horizons for research and therapy of human Neurodevelopmental Disorders (NDDs)” as part of the project STREAMLINE funded by the European Union. The School will be held at the Institute of Molecular Genetics and Genetic Engineering, University of Belgrade (IMGGE), Belgrade, Serbia from April 9th to April 11th 2025 and will be co-organized by IMGGE and Cardiff University, UK.
Why STREAMLINE International School: The School will offer a comprehensive guide to current state-of-the-art research of NDDs based on the application of patient-specific induced pluripotent stem cells (iPSCs), brain organoids and OMICS analysis. By face-to-face lectures, discussion sessions and practical demonstrations, the International School will guide you from the understanding of the clinical perspective of NDDs, human cell functional genomics, modelling NDDs using iPSCs and brain organoids, emerging imaging technologies to study cell architecture, dynamics and function to the translation from cell mechanism to patient biology. It will provide knowledge and understanding of current approaches and technologies to support future research and international collaboration.
Who should attend this International Streamline School: PhD students from the Western Balkan region with interest in research and therapy of NDDs.
Costs: travel (train/bus tickets), accommodation and subsistence costs will be covered by the project STREAMLINE.
Language: English
How to apply: Please apply via the Google form at the link or scan QR code below
Selection procedure: To enable comfortable interactions between the instructors and attendees, the numbers of participants will be limited to a maximum of 25. The selection will be based on qualification, current work, and motivation letter regarding the ongoing or future research within the field of NDDs.
Decisions on acceptance will be announced by email on February 7th.
On Thursday, December 12, Jovana Kostić and Jelena Pejić visited the vocational school in Aranđelovac where they presented the STREAMLINE project, funded by the EU, and introduced the high school students to the latest methods in modeling neurodevelopmental disorders. This was the great opportunity for high school students to get familiarized with the latest results of STREAMLINE project.
It is our great pleasure to share that dr Danijela Stanisavljević Ninković, a member of STREAMLINE team, has been awarded an #IBROSpeakerSupport grant for the 22q11.2 Deletion Syndrome Symposium!
The International Brain Research Organization (IBRO) is the global association of neuroscience societies established in 1961 that aims to promote and support neuroscience around the world through training, education, research, outreach and engagement activities, and the publication of two journals, Neuroscience and IBRO Neuroscience Reports.
The 22q11.2 Deletion Syndrome Symposium offers a unique opportunity for parents and children affected by the condition to connect, share experiences, and gain valuable insights. Participants will benefit from the knowledge of leading specialists in Serbia and across Europe, who will present the latest advancements in research, diagnostics, and management of 22q11.2 Deletion Syndrome, including its associated risks for neurodevelopmental disorders. We have carefully selected speakers with extensive expertise, ensuring a comprehensive and engaging program. This event also serves to strengthen the connections established during the STREAMLINE project, and we are deeply grateful to IBRO for supporting this initiative. Details about registration will be announced soon. Stay tuned for updates about the Symposium, which will take place on November 22, 2025.
On Friday, November 22th, the third Symposium entitled “22q Awareness Day ” was organized within the STREAMLINE project. We gathered around researchers, doctors, parents and children living with 22q11 deletion syndrome. This was another wonderful meeting with the hope that it will grow into a tradition. The Symposium started with Dr. Danijela Drakulić who presented STREAMLINE projects activities. Her opening speech was followed by from representatives of National organization for rare diseases of Serbia (NORBS) and “22q ex YU”, Stefan Živković and Vesna Vujičić, who talked about the current activities of their associations. At the end of opening speech Ana Knežević (President of inclusive center “Here’s a hand” (Evo ruka)) said that her message is that we should help to parents and children living with 22q11 deletion syndrome. STREAMLINE team members spent this wonderful evening with parents and children living with 22q11 deletion syndrome, enjoying in good talk and music. This was a great opportunity to better understand the life of people with 22q11.2 deletion syndrome and their daily struggles, but also to become familiar with their way of thinking and their many talents. Perhaps the most important thing is that this Symposium enabled parents who share the same problems to exchange experiences, to broaden perspectives, and create new contacts.
Choosing a professional path is one of the most frequent problems students have in career counseling. Therefore, on November 8th, as part of the “Find out first-hand” program, the Center for Career Development and Student Counseling of the University of Belgrade and the Institute for Molecular Genetics and Genetic Engineering (IMGGI) of the University of Belgrade, organized a visit for final year students from the different faculties of natural sciences, University of Belgrade. Students had the opportunity to become more familiar with IMGGI, projects, and career planning possibilities. Dr Mina Perić described students how it is to work with human induced pluripotent cells technology, an exciting new era for the fields of stem cell biology and regenerative medicine, as well as disease modeling and drug discovery.
November 22nd is the International 22q11 Day, with initiative to increase awareness about 22q11.2 deletion syndrome (22q11.2DS) by wearing a red wardrobe and lighting several buildings in red around the Europe. 22q11.2DS is a genetic disorder caused by a heterozygous microdeletion of region q11.2 of chromosome 22. It is the most common microdeletion syndrome in humans with an estimated incidence of approximately 1/4000 per live births. After Down syndrome, 22q11.2 deletion syndrome is the second most common cause of developmental delay and congenital heart diseases. The spectrum of clinical manifestations in patients with this syndrome is very variable, even within the same family. Approximately, 25% of patients with 22q11.2DS develop schizophrenia. Intellectual disability is detected in approximately 45% of patients with 22q11.2DS, while Autism Spectrum Disorder is seen in 14-50% of cases. It accounts for approximately 2.4% of people with developmental disabilities and approximately 10% to 15% of people with Tetralogy of Fallot (a type of heart defect). Males and females of all ethnic backgrounds are affected in equal numbers.
A diagnosis is quite challenging for 22q11 individuals due to their extremely diverse range of symptoms. Actually, 50% of people with 22q11 never receive a diagnosis. However, early treatment of the symptoms can lessen their severity, thus a person with 22q11 can have a far better life if diagnosed early. Additionally, early diagnosis helps educators better adjusting the learning environment, health experts better modifying their treatments, and parents better preparing for the arrival of their kid. Increasing public knowledge will thus lead to earlier illness diagnosis and better treatment.
Congratulations to Academician Milena Stevanović, who was awarded for her contribution to the development of molecular biology in Serbia by the Serbian Society for Molecular Biology (MolBioS). The award ceremony took place at the Serbian Academy of Sciences and Arts on October 8th. Prof. Dr. Gordana Matić highlighted Academician Milena Stevanović’s significant contributions to genetic engineering, human molecular genetics, elucidating molecular mechanisms of oncogenesis and neurogenesis, as well as disease modeling. Academician Milena Stevanović also made a great impact on the Faculty of Biology at the University of Belgrade through her dedication to student education. Prof. Dr. Gordana Matić also emphasized that Academician Milena Stevanović should be regarded as a symbol of molecular biology in Serbia.
Additionally, Prof. Dr. Goran Brajušković acknowledged Academician Milena Stevanović’s substantial contributions to the development and promotion of molecular biology in Serbia. At the conclusion, Academician Milena Stevanović shared her journey from her early days as a student, from her first SOX gene cloning to the first images of human induced pluripotent stem cells generated in Serbia, highlighting the beauty of molecular biology.
Academician Milena Stevanović considers her greatest success to be leaving a laboratory full of researchers capable of independently carrying on the research work.
VII Congress of the Serbian Genetic Society was held from October 2nd to October 5th, 2024. at Zlatibor mountain of extraordinary beauty, and pleasant climate. This Congress covered many fields of genetics including molecular genetics and genomics, medical genetics and personalized medicine, population and evolutionary genetics, microbial genetics, breeding and genetic engineering, genotoxicology, new technologies, and others. This was a great opportunity to increase the visibility of the STREAMLINE Project and STREAMLINE hub among academic public. Accordingly, within the congress STREAMLINE team organized thematic workshop: “STREAMLINE hub for modelling disease and discovering molecular mechanisms of neurodevelopmental disorders”. The majority of attendees was Congress participants that had an opportunity to learn about the latest iPSCs-based approaches for studying neurodevelopmental disorders, as well as to join STREAMLINE hub.
As invited speaker, dr Danijela Drakulic, presented STREAMLINE outputs through lecture “Establishment of a model system for studying neurodevelopmental disorders using induced pluripotent stem cells derived from patients with 22q11.2 Deletion” within session Medical genetics. The main focused of the lecture was on STREAMLINE Exploratory Research Project and how far we have come in designing a new iPSCs-based tool for unveiling neuropathological mechanisms of human neurodevelopmental disorders.
During poster sesions, the youngest STREAMLINE team members Jovana Kostić and Ivana Simeunović presented their PhD topics in form of posters – “Patient-derived induced pluripotent stem cells with 22q11.2 microdeletion: a model system for investigating neurodevelopmental disorders” and “Characterization of induced pluripotent stem cells from patients with 22q11.2 Duplication Syndrome”, subsequently. Particularly, they briefly introduced the establishment of iPSCs from patients with 22q11.2 duplication and deletion syndrome as model systems for studying neurodevelopmental disorders.
In the period from 23rd to 27th September, PhD students from STREAMLINE team Stefan Lazić, Jelena Pejić, Luka Bojić, Jovana Kostić and Ivana Simeunović attended the course Multi-Omics and Data Sciences in Complex Disease held at the University of Maastricht, the Netherlands. The course is organized by the Netherlands School of Bioinformatics and Systems Biology (BioSB), which focuses on knowledge exchange and training in these areas.
During their stay in the Netherlands, they had the opportunity to hear more about current developments in the field of epigenomics, epigenome wide association studies (EWAS), as well as to apply the knowledge in practice on examples. In addition, the topics of the course were related to the design of studies in molecular epidemiology, machine learning, but also the integration of different types of data. Participants also had the opportunity to talk to experts in these fields about their experiments and analysis of their own data.
Thanks again to organizers from Netherlands School of Bioinformatics and Systems Biology from Maastricht for this great opportunity.